Glycotope outlicenses GlycoExpress® Cell Line to Airway Therapeutics


Glycotope outlicenses GlycoExpress® Cell Line to Airway Therapeutics

Berlin, Germany, 19 September 2017 - Glycotope GmbH [Glycotope], a clinical-stage immuno-oncology company built on world-leading glyco-biology expertise, today announced an exclusive licensing agreement with Airway Therapeutics, LLC, [Airway] a biotech company focused on developing new interventions for acute and chronic lung diseases. Under the terms of this agreement, Airway receives worldwide commercial rights to use Glycotope's proprietary cell line technology, GlycoExpress® [GEX®], for use in AT-100 (rhSP-D), one of Airway's development programs. The GlycoExpress® technology has been shown to be well suited to the development and large-scale manufacturing of a wide range of biologics including antibodies as well as complex and difficult to express proteins.

"We are pleased to enter into this agreement with Glycotope and reach another significant milestone on AT-100's path to market.  Our manufacturing development is on track and on schedule," said Marc Salzberg, MD, President and CEO of Airway Therapeutics.

The Glycotope cell line is designed to optimize the manufacturing of AT-100. Advantages include high-yield production of Airway's protein, fast production cycles and the provision of human glycosylation patterns. The extraordinarily efficient cell line has produced high-quality protein and will serve as the basis for the production of Airway's protein for use in humans. 

"We are very pleased to be working with Airway on this highly challenging and exciting project. Compared to CHO cells, the GlycoExpress® technology has been shown to be a superior expression host for this difficult to express protein," said Henner Kollenberg, Managing Director at Glycotope.

About Glycotope:

Glycotope, founded in 2000 in Berlin, focuses on the development of innovative immune-oncological products for the treatment of various cancer types using their GlycoBody and GlycoExpress® technologies. Glycotope has currently two products in advanced clinical development. The Company's additional pipeline includes preclinical non-antibody and antibody biopharmaceuticals for various indications.

Glycotope's GlycoExpress® (GEX®) platform allows glyco-optimization and high yield production of a variety of fully human glycosylated biopharmaceuticals such as antibodies, glycoprotein hormones, coagulation factors and cytokines, and by using a toolbox of glyco-engineered proprietary human cell lines that allow for optimization of a whole series of different determining sugars. In addition, the GEX® platform can be used for in process glycosylation control.

About BPD (Bronchopulmonary Dysplasia):

is caused by arrested lung development in premature neonates and can lead to death or life long lung and neurodevelopment conditions. Today, current therapies lack critical proteins necessary to prevent the onset of BPD.

Approximately 160,000 preterm babies are at high risk to get BPD each year in North America and Europe of which 20% can be expected to get BPD and approximately 50% of these patients may die.

About Airway Therapeutics:

AIRWAY is a biotech company focused on developing new interventions for acute and chronic lung diseases in the most vulnerable of patients. Founded in 2011 as a spin-out of Cincinnati Children's Hospital Medical Center, Airway Therapeutics has extensive expertise in protein development for applications in the lungs and pediatrics. Airway Therapeutics is currently developing an investigational product, AT-100, a recombinant form of human surfactant protein-D (rhSP-D), for the prevention of a serious lung condition called bronchopulmonary dysplasia (BPD) in preterm born babies.

For more information about Glycotope, please contact Lars Stöckl at

For more information about Airway Therapeutics, please contact Sandra Roberts at

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Source: Glycotope via GlobeNewswire